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ea0011p244 | Cytokines and growth factors | ECE2006

CD4 T-cell count improves during sustained IGF-I response following low dose growth hormone therapy in HIV-infected patients on stable antiretroviral regimens. A pilot study

Andersen O , Hansen BR , Flyvbjerg A , Madsbad S , Ørskov H , Nielsen JO , Iversen J , Haugaard SB

Objective: High dose growth hormone (rhGH) regimens (2 to 4 mg/day) have been shown to increase circulating insulin-like growth factor (IGF)-I to supra-physiological levels in human immunodeficiency virus (HIV)-infected patients on combined antiretroviral therapy (CART). This setting may improve immunologic output. However, a high plasma IGF-I concentration has detrimental effects on glucose metabolism, which hampers the use of high dose rhGH regimens.Me...

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CD4 T-cell count improves during sustained IGF-I response following low dose growth hormone therapy in HIV-infected patients on stable antiretroviral regimens. A pilot study

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